In-Vivo Study of Bioceramics in Order to Make Bone Prosthes

Purpose: There are a lot of experiences about using bone-like materials in order to replace bone defects, especially those which are caused by cancer therapy. The most suitable materials for this purpose are bioceramics. The investigations have been shown that bioceramics are able to induce proliferation of osteoblast as well as bone matrix synthesis in - vivo.The aim of the present study is to investigate the body response to alumina, as an engineering bioceramic material, for repairing the bone defects and to make bone prosthes. Materials and Methods: Under controlled anesthesia 20 mg/kg of alumina was implanted in several regions of subcutaneous of adult rabbit and Balb/c mice. After one and two months, respectively the skin samples were aparted, fixed, sectioned and stained using hematexylen and eosin method. Then they were observed and evaluated under light microscope. Results: The results showed no inflammatory response to aluminas and no morphologically differences on the skin surface in comparison with the control group. Conclusion: It can be concluded that this kind of bioceramic, "alumia", can be used to produce bone model and is able to replace the bone defects due to cancer therapy.